Anti-JAM1 Rabbit Monoclonal Antibody, Clone#RM275

Boster Bio Anti-JAM1 Rabbit Monoclonal Antibody, Clone#RM275 (Catalog # M02068-1) . Tested in IHC, WB applications. This antibody reacts with Human.

Product Specifications

Synonyms

Junctional adhesion molecule A; JAM-A; Junctional adhesion molecule 1; JAM-1; Platelet F11 receptor; Platelet adhesion molecule 1; PAM-1; CD321; F11R; JAM1, JCAM; UNQ264/PRO301

Gene Name

F11R

UniProt

Q9Y624

Host

Rabbit

Reactivity

Human

Cross Reactivity

This antibody reacts to human JAM1 (Junctional adhesion molecule 1) .

Immunogen

A peptide corresponding to the N-terminus of human human JAM1 (Junctional adhesion molecule 1) .

Clonality

Monoclonal

Clone

Clone: RM275

Tissue Specificity

Expressed in endothelium, epithelium and leukocytes (at protein level) .

Applications

IHC, WB

Field of Research

Atherosclerosis, Cardiovascular, Cell Adhesion, Cytoskeleton/ECM, Platelets, Signal Transduction, Tight Junctions, Vascular Inflammation

Purification

Protein A affinity purified from an animal origin-free culture supernatant

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed:11489913) . The association of the PARD6- PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity) . Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity) . Ligand for integrin alpha- L/beta-2 involved in memory T-cell and neutrophil transmigration (PubMed:11812992) . Involved in platelet activation (PubMed:10753840) .

Molecular Weight

32583 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. Avoid repeated freeze-thaw cycles.

Fragment

Rabbit IgG

Other Gene Names

Junctional adhesion molecule A

Subcellular Location

Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein. Localized at tight junctions of both epithelial and endothelial cells.