Anti-MART1 MLANA Rabbit Monoclonal Antibody, Clone#RM333

Boster Bio Anti-MART1 MLANA Rabbit Monoclonal Antibody, Clone#RM333 (Catalog # M02033-2) . Tested in IHC, WB applications. This antibody reacts with Human.

Product Specifications

Synonyms

Melanoma antigen recognized by T-cells 1; MART-1; Antigen LB39-AA; Antigen SK29-AA; Protein Melan-A; MLANA; MART1

Gene Name

MLANA

UniProt

Q16655

Host

Rabbit

Reactivity

Human

Cross Reactivity

This antibody reacts to human MART1 (Melanoma antigen recognized by T-cells-1) .

Immunogen

A peptide corresponding to the N-terminus of human MART1 (Melanoma antigen recognized by T-cells-1) .

Clonality

Monoclonal

Clone

Clone: RM333

Tissue Specificity

Expression is restricted to melanoma and melanocyte cell lines and retina.

Applications

IHC, WB

Field of Research

Cancer, Cell Type Markers, Tags & Cell Markers, Tumor Associated, Tumor Immunology, Tumor-Associated Antigens

Purification

Protein A affinity purified from an animal origin-free culture supernatant

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.

Molecular Weight

13157 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. Avoid repeated freeze-thaw cycles.

Fragment

Rabbit IgG

Other Gene Names

Melanoma antigen recognized by T-cells 1

Subcellular Location

Endoplasmic reticulum membrane; Single-pass type III membrane protein. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane. Melanosome. Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post- Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.