Anti-N-Cadherin-2 CDH2 CD325-Rabbit Monoclonal Antibody, Clone#RM259

Boster Bio Anti-N-Cadherin-2 CDH2 CD325-Rabbit Monoclonal Antibody, Clone#RM259 (Catalog # M01577-2) . Tested in WB applications. This antibody reacts with Human.

Product Specifications

Synonyms

Cadherin-2; CDw325; Neural cadherin; N-cadherin; CD325; CDH2; CDHN, NCAD

Gene Name

CDH2

UniProt

P19022

Host

Rabbit

Reactivity

Human

Cross Reactivity

This antibody reacts to human N-cadherin. This antibody may also react to mouse or rat N-cadherin, as predicted by immunogen homology.

Immunogen

A peptide corresponding to Human N-Cadherin

Clonality

Monoclonal

Clone

Clone: RM259

Applications

Field of Research

Cadherins, Cell Adhesion, Cytoskeleton/ECM, Signal Transduction

Purification

Protein A affinity purified from an animal origin-free culture supernatant

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Dilution

WB: 1:1000-1:2000 dilution

Form

Liquid

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity) .

Molecular Weight

99809 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. Avoid repeated freeze-thaw cycles.

Fragment

Rabbit IgG

Other Gene Names

Cadherin-2

Subcellular Location

Cell membrane; Single-pass type I membrane protein. Cell membrane, sarcolemma. Cell junction. Cell surface. Colocalizes with TMEM65 at the intercalated disk in cardiomyocytes. Colocalizes with OBSCN at the intercalated disk and at sarcolemma in cardiomyocytes.