Anti-TTF1 (Thyroid transcription factor 1) NKX2-1 Rabbit Monoclonal Antibody, Clone#RM373

Boster Bio Anti-TTF1 (Thyroid transcription factor 1) NKX2-1 Rabbit Monoclonal Antibody, Clone#RM373 (Catalog # M01322-2) . Tested in IHC, WB applications. This antibody reacts with Human.

Product Specifications

Synonyms

Homeobox protein Nkx-2.1; Homeobox protein NK-2 homolog A; Thyroid nuclear factor 1; Thyroid transcription factor 1; TTF-1; Thyroid-specific enhancer-binding protein; T/EBP; NKX2-1 ; NKX2A, TITF1, TTF1

Gene Name

NKX2-1

UniProt

P43699

Host

Rabbit

Reactivity

Human

Cross Reactivity

This antibody reacts to human TTF1 ((Thyroid transcription factor 1) (Homeobox protein Nkx-2.1) . It may also react to mouse and rat TTF1, as predicted by immunogen homology.

Immunogen

A peptide corresponding to N-terminus of human TTF1 (Thyroid transcription factor 1) (Homeobox protein Nkx-2.1)

Clonality

Monoclonal

Clone

Clone: RM373

Tissue Specificity

Thyroid and lung.

Applications

IHC, WB

Field of Research

Epigenetics and Nuclear Signaling, Transcription

Purification

Protein A affinity purified from an animal origin-free culture supernatant

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 (By similarity) .