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Anti-MDC1 Monoclonal Antibody

Boster Bio Anti-MDC1 Monoclonal Antibody catalog # M01252. Tested in IF, ICC, WB applications. This antibody reacts with Human, Mouse.

Product Specifications

Background

MDC1, mediator of DNA damage checkpoint protein 1, plays a role in checkpoint mediated cell cycle arrest in response to DNA damage, within S phase and G2/M. It is also thought to act as a scaffold protein during recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage that are marked by phosphorylation of histone H2A.X on S139.

Synonyms

Nuclear factor with BRCT domains1, mediator of DNA damage checkpoint 1

Gene Name

MDC1

UniProt

Q5PSV9

Host

Mouse

Reactivity

Human, Mouse, Bovine, Chimpanzee

Cross Reactivity

Detects ~184kDa. This antibody recognizes MDC1 at and around the N-terminus.

Immunogen

GST-tagged recombinant protein corresponding to mouse MDC1 at and around the N-terminus

Clonality

Monoclonal

Clone

Clone: P2B11

Applications

WB, ICC, IF

Field of Research

DNA/RNA, DNA Damage & Repair, DNA Damage Response, Epigenetics and Nuclear Signaling

Purification

Protein G Purified

Sensitivity

>5000 cells

Concentration

1 mg/ml

Dilution

WB (1:2000), ICC/IF (1:100) ; optimal dilutions for assays should be determined by the user.

Form

Liquid

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=M01252

Product MSDS

https://www.bosterbio.com/msds?sku=M01252

Fragment

IgG1

Subcellular Location

Nucleus

Protein Name

MDC1

Curated Selection

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