L-Leucine-15N, d10
L-Leucine-15N, d10 is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].
Product Specifications
UNSPSC
12352211
Target
Endogenous Metabolite; mTOR
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; PI3K/Akt/mTOR
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Solubility
10 mM in DMSO
Smiles
[15NH2][C@@](C(O)=O)([2H])C([2H])([2H])C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H]
Molecular Formula
C6H3D10 15NO2
Molecular Weight
142.23
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Baoshan Xu, et al. Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet. 2013;9 (10) :e1003857.|[3]Bruckbauer A, et al. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond) . 2012 Aug 229 (1) :77.|[4]Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb61 (2) :409-17.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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