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Anti-Doublecortin/DCX Monoclonal Antibody

Boster Bio Anti-Doublecortin/DCX Monoclonal Antibody catalog # M01053-1. Tested in IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Neuronal migration protein doublecortin; Doublin; Lissencephalin-X; Lis-X; DCX; DBCN, LISX

Gene Name

DCX

UniProt

O43602

Host

Mouse

Reactivity

Human, Rat, Mouse

Immunogen

Recombinant full length human Lis-A isoform of DCX purified from E. coli.

Clonality

Monoclonal

Tissue Specificity

Highly expressed in neuronal cells of fetal brain (in the majority of cells of the cortical plate, intermediate zone and ventricular zone), but not expressed in other fetal tissues. In the adult, highly expressed in the brain frontal lobe, but very low expression in other regions of brain, and not detected in heart, placenta, lung, liver, skeletal muscles, kidney and pancreas.

Applications

IHC, WB, IF, ICC

Field of Research

Cancer, Energy Metabolism, Energy Transfer Pathways, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Dilution

WB: 1:10,000. IF/ICC and IHC: 1:1,000.

Function

Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration. .

Molecular Weight

40574 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=M01053-1

Product MSDS

https://www.bosterbio.com/msds?sku=M01053-1

Other Gene Names

Neuronal migration protein doublecortin

Subcellular Location

Cytoplasm . Cell projection . Localizes at neurite tips. .

Curated Selection

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