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Anti-CD79a (C-term) Rabbit Monoclonal Antibody, Clone#RM297

Boster Bio Anti-CD79a (C-term) Rabbit Monoclonal Antibody, Clone#RM297 (Catalog # M01047-2) . Tested in IHC, WB applications. This antibody reacts with Human.

Product Specifications

Synonyms

B-cell antigen receptor complex-associated protein alpha chain; Ig-alpha; MB-1 membrane glycoprotein; Membrane-bound immunoglobulin-associated protein; Surface IgM-associated protein; CD79a; CD79A; IGA, MB1

Gene Name

CD79A

UniProt

P11912

Host

Rabbit

Reactivity

Human

Cross Reactivity

This antibody reacts to human CD79a

Immunogen

A peptide corresponding to the C-terminus of human CD79a

Clonality

Monoclonal

Clone

Clone: RM297

Tissue Specificity

B-cells.

Applications

IHC, WB

Field of Research

Adaptive Immunity, B Cells, Cancer, Hematopoietic Progenitors, Immunoglobulins, Immunology, Lymphoid, Receptors, Stem Cells, Tumor Immunology

Purification

Protein A affinity purified from an animal origin-free culture supernatant

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src- family tyrosine kinases. Represses BCR signaling during development of immature B-cells.

Molecular Weight

25038 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=M01047-2

Product MSDS

https://www.bosterbio.com/msds?sku=M01047-2

Fragment

Rabbit IgG

Other Gene Names

B-cell antigen receptor complex-associated protein alpha chain

Subcellular Location

Cell membrane; Single-pass type I membrane protein. Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.
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