Anti-BCMA Tnfrsf17 Antibody (Monoclonal, Vicky-2)

Boster Bio Anti-BCMA Tnfrsf17 Antibody (Monoclonal, Vicky-2) catalog # M01014. Tested in IP, WB applications. This antibody reacts with Mouse.

Product Specifications

Background

TNFRSF17 (Tumor necrosis factor receptor superfamily member 17), also called BCMA, is a protein that in humans is encoded by the TNFRSF17 gene. The protein encoded by this gene is a member of the TNF-receptor superfamily and is mapped to 16p13.13. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.

Synonyms

Tumor necrosis factor receptor superfamily member 17; B-cell maturation protein; CD269; Tnfrsf17; Bcm, Bcma

Gene Name

Tnfrsf17

UniProt

O88472

Host

Rat

Reactivity

Mouse

Cross Reactivity

No cross reactivity with other proteins.

Immunogen

Recombinant mouse BCMA extracellular domain (aa 1-46) .

Clonality

Monoclonal

Clone

Clone: Vicky-2

Tissue Specificity

Detected in spleen, thymus, bone marrow and heart, and at lower levels in kidney and lung.

Applications

IP, WB

Field of Research

Antiviral Signaling, Cancer, Growth Factors, Growth Factors/Hormones, Immune System Diseases, Immunology, Signal Transduction

Purification

Protein G-affinity purified.

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK (By similarity) . .