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Anti-TDP43 TARDBP Monoclonal Antibody

Boster Bio Anti-TDP43 TARDBP Monoclonal Antibody catalog # M01001-1. Tested in IF, IHC, ICC, WB applications. This antibody reacts with Bovine, Equine, Human, Mouse, Pig, Rat.

Product Specifications

Synonyms

TAR DNA-binding protein 43; TDP-43; TARDBP; TDP43

Gene Name

TARDBP

UniProt

Q13148

Host

Mouse

Reactivity

Human, Rat, Mouse, Bovine, Pig, Equine

Immunogen

E. coli

Clonality

Monoclonal

Tissue Specificity

Ubiquitously expressed. In particular, expression is high in pancreas, placenta, lung, genital tract and spleen.

Applications

IHC, WB, IF, ICC

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Dilution

WB: 1:5,000. ICC/IF and IHC 1:1,000

Function

DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR. .

Molecular Weight

44740 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=M01001-1

Product MSDS

https://www.bosterbio.com/msds?sku=M01001-1

Other Gene Names

TAR DNA-binding protein 43

Subcellular Location

Nucleus . In patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis, it is absent from the nucleus of affected neurons but it is the primary component of cytoplasmic ubiquitin-positive inclusion bodies.
Curated Selection

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