Anti-S100-beta Rabbit Monoclonal Antibody, Clone#RM304

Boster Bio Anti-S100-beta Rabbit Monoclonal Antibody, Clone#RM304 (Catalog # M00979-2) . Tested in IHC, WB applications. This antibody reacts with Human.

Product Specifications

Synonyms

Protein S100-B; S-100 protein beta chain; S-100 protein subunit beta; S100 calcium-binding protein B; S100B

Gene Name

S100B

UniProt

P04271

Host

Rabbit

Reactivity

Human

Cross Reactivity

This antibody reacts to human S100-B (S-100 protein beta chain) . It may also react to mouse or rat S100-B, as predicted by immunogen homology.

Immunogen

A peptide corresponding to the C-terminus of human S100-B

Clonality

Monoclonal

Clone

Clone: RM304

Tissue Specificity

Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues.

Applications

IHC, WB

Field of Research

Cell Biology, Cell Cycle, Cell Differentiation, Epigenetics and Nuclear Signaling, Neural Stem Cells, Stem Cells

Purification

Protein A affinity purified from an animal origin-free culture supernatant

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.