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Anti-CD45 PTPRC Rabbit Monoclonal Antibody, Clone#RM291

Boster Bio Anti-CD45 PTPRC Rabbit Monoclonal Antibody, Clone#RM291 (Catalog # M00555-2) . Tested in IHC, WB applications. This antibody reacts with Human.

Product Specifications

Synonyms

Receptor-type tyrosine-protein phosphatase C;3.1.3.48; Leukocyte common antigen; L-CA; T200; CD45; PTPRC; CD45

Gene Name

PTPRC

UniProt

P08575

Host

Rabbit

Reactivity

Human

Cross Reactivity

This antibody reacts to human CD45 (Receptor-type tyrosine-protein phosphatase C) .

Immunogen

A peptide corresponding to the C-terminus of human CD45 (Receptor-type tyrosine-protein phosphatase C) .

Clonality

Monoclonal

Clone

Clone: RM291

Applications

IHC, WB

Field of Research

Adapters, Adaptive Immunity, B Cells, Cell Type Markers, Immunology, Protein Phosphorylation, Signal Transduction, T Cells, Transmembrane, Tyrosine Phosphatases

Purification

Protein A affinity purified from an animal origin-free culture supernatant

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity) .

Molecular Weight

147254 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=M00555-2

Product MSDS

https://www.bosterbio.com/msds?sku=M00555-2

Fragment

Rabbit IgG

Other Gene Names

Receptor-type tyrosine-protein phosphatase C

Subcellular Location

Membrane; Single-pass type I membrane protein. Membrane raft. Colocalized with DPP4 in membrane rafts.

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