Anti-PR (Progesterone Receptor) PGR Rabbit Monoclonal Antibody, Clone#RM357

Boster Bio Anti-PR (Progesterone Receptor) PGR Rabbit Monoclonal Antibody, Clone#RM357 (Catalog # M00541-3) . Tested in IHC, WB applications. This antibody reacts with Human.

Product Specifications

Synonyms

Progesterone receptor; PR; Nuclear receptor subfamily 3 group C member 3; PGR; NR3C3

Gene Name

PGR

UniProt

P06401

Host

Rabbit

Reactivity

Human

Cross Reactivity

This antibody reacts to human Progesterone Receptor (PR) . It may also react to mouse and rat PR, as predicted by immunogen homology

Immunogen

A peptide corresponding to C-terminus of human Progesterone Receptor.

Clonality

Monoclonal

Clone

Clone: RM357

Tissue Specificity

In reproductive tissues the expression of isoform A and isoform B varies as a consequence of developmental and hormonal status. Isoform A and isoform B are expressed in comparable levels in uterine glandular epithelium during the proliferative phase of the menstrual cycle. Expression of isoform B but not of isoform A persists in the glands during mid-secretory phase. In the stroma, isoform A is the predominant form throughout the cycle. Heterogeneous isoform expression between the glands of the endometrium basalis and functionalis is implying region- specific responses to hormonal stimuli.

Applications

IHC, WB

Field of Research

Cancer, Domain Families, Endocrine System, Epigenetics and Nuclear Signaling, Neuroscience, Nuclear Hormone Receptors, Nuclear Receptors, Nuclear Signaling Pathways, Signal Transduction, Signaling Pathway, Transcription, Tumor Biomarkers, Zinc Finger

Purification

Protein A affinity purified from an animal origin-free culture supernatant

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor.

Molecular Weight

98981 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. Avoid repeated freeze-thaw cycles.

Fragment

Rabbit IgG

Other Gene Names

Progesterone receptor

Subcellular Location

Nucleus. Cytoplasm. Nucleoplasmic shuttling is both homone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G (1) and G (2) /M phases.