Anti-Integrin alpha 4 (ITGA4) Rabbit Monoclonal Antibody, Clone#RM268

Boster Bio Anti-Integrin alpha 4 (ITGA4) Rabbit Monoclonal Antibody, Clone#RM268 (Catalog # M00468-1) . Tested in IHC, WB applications. This antibody reacts with Human.

Product Specifications

Synonyms

Integrin alpha-4; CD49 antigen-like family member D; Integrin alpha-IV; VLA-4 subunit alpha; CD49d; ITGA4; CD49D

Gene Name

ITGA4

UniProt

P13612

Host

Rabbit

Reactivity

Human

Cross Reactivity

This antibody reacts to the cytoplasmic domain of human Integrin alpha 4 (ITGA4) .

Immunogen

A peptide corresponding to the C-terminus of human Integrin alpha 4 (ITGA4) .

Clonality

Monoclonal

Clone

Clone: RM268

Applications

IHC, WB

Field of Research

Cell Adhesion, Cell Type Markers, Cytoskeleton/ECM, Immunology, Integrins, Neural Stem Cells, Signal Transduction, Stem Cells, Surface Molecules

Purification

Protein A affinity purified from an animal origin-free culture supernatant

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha- 4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha- 4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415) . ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877) .