Anti-MUM1/IRF4 Rabbit Monoclonal Antibody, Clone#RM352

Boster Bio Anti-MUM1/IRF4 Rabbit Monoclonal Antibody, Clone#RM352 (Catalog # M00401-1) . Tested in IHC, WB applications. This antibody reacts with Human.

Product Specifications

Synonyms

Interferon regulatory factor 4; IRF-4; Lymphocyte-specific interferon regulatory factor; LSIRF; Multiple myeloma oncogene 1; NF-EM5; IRF4; MUM1

Gene Name

IRF4

UniProt

Q15306

Host

Rabbit

Reactivity

Human

Cross Reactivity

This antibody reacts to human MUM1/IRF4 (Interferon regulatory factor 4) .

Immunogen

A peptide corresponding to the C-terminus of human MUM1/IRF4.

Clonality

Monoclonal

Clone

Clone: RM352

Tissue Specificity

Lymphoid cells.

Applications

IHC, WB

Field of Research

Cancer, Cancer Susceptibility, Cell Type Markers, Epigenetics and Nuclear Signaling, Oncoproteins, Oncoproteins/Suppressors, Proto-Oncogenes, Tags & Cell Markers, Transcription, Transcription Factors, Tumor Associated

Purification

Protein A affinity purified from an animal origin-free culture supernatant

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Transcriptional activator. Binds to the interferon- stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8 (+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes (By similarity) .