Anti-Caspase-3 Rabbit Monoclonal Antibody, Clone#RM250
Boster Bio Anti-Caspase-3 Rabbit Monoclonal Antibody, Clone#RM250 (Catalog # M00334-8) . Tested in IHC, WB applications. This antibody reacts with Human.
Product Specifications
Synonyms
Caspase-3; CASP-3;3.4.22.56; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1; Caspase-3 subunit p17; Caspase-3 subunit p12; CASP3; CPP32
Gene Name
CASP3
UniProt
P42574
Host
Rabbit
Reactivity
Human
Cross Reactivity
This antibody reacts to human full length caspase-3 (35 kDa) and the large fragment of caspase-3 resulting from cleavage (17 kDa) .
Immunogen
A synthetic peptide corresponding to residues within human Caspase-3 subunit p17
Clonality
Monoclonal
Clone
Clone: RM250
Tissue Specificity
Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.
Applications
IHC, WB
Field of Research
Alzheimer's Disease, Apoptosis, Apoptotic Markers, Cancer, Caspases, Cell Biology, Cell Death, Intracellular, Invasion/Microenvironment, Neurodegenerative Disease, Neurology Process, Neuroscience
Purification
Protein A affinity purified from an animal origin-free culture supernatant
Concentration
0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Form
Liquid
Function
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly (ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.
Molecular Weight
31608 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. Avoid repeated freeze-thaw cycles.
Fragment
Rabbit IgG
Other Gene Names
Caspase-3
Subcellular Location
Cytoplasm.
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