What is the catalog number for Anti-Ki-67 MKI67 Antibody?

The catalog number for Anti-Ki-67 MKI67 Antibody is M00254-4.

Is Anti-Ki-67 MKI67 Antibody in stock?

Anti-Ki-67 MKI67 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Where can I find the safety data sheet (SDS/MSDS) for Anti-Ki-67 MKI67 Antibody?

The safety data sheet for Anti-Ki-67 MKI67 Antibody is available here: https://www.bosterbio.com/msds?sku=M00254-4.

Anti-Ki-67 MKI67 Antibody

Boster Bio Anti-Ki-67 MKI67 Antibody catalog # M00254-4. Tested in IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Proliferation marker protein Ki-67 ; Antigen identified by monoclonal antibody Ki-67 ; Antigen KI-67 ; Antigen Ki67 ; MKI67

Gene Name

MKI67

UniProt

P46013

Host

Chicken

Reactivity

Human, Rat, Mouse

Immunogen

Mixture of recombinant human Ki-67 constructs expressing the N-terminal region, amino acids 1-300 and an internal region, amino acids 1111-1490

Clonality

Polyclonal

Applications

IF, IHC, ICC, WB

Field of Research

Cancer, Cell Biology, Cell Cycle, Cell Division, Cell Type Marker, Cell Type Markers, Neurogenesis, Neurology Process, Neuron Marker, Neuroscience, Tags & Cell Markers, Tumor Biomarkers

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Function

Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226) . Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226) . Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226) . Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551) . Does not contribute to the internal structure of mitotic chromosomes (By similarity) . May play a role in chromatin organization (PubMed:24867636) . It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable) . .

Molecular Weight

358694 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Other Gene Names

Proliferation marker protein Ki-67

Subcellular Location

Chromosome . Nucleus . Nucleus, nucleolus . Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the mitotic chromosome surface (PubMed:27362226) . Associates with satellite DNA in G1 phase (PubMed:9510506) . Binds tightly to chromatin in interphase, chromatin-binding decreases in mitosis when it associates with the surface of the condensed chromosomes (PubMed:15896774, PubMed:22002106) . Predominantly localized in the G1 phase in the perinucleolar region, in the later phases it is also detected throughout the nuclear interior, being predominantly localized in the nuclear matrix (PubMed:22002106) . .