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Anti-p27Kip1 (Cyclin-dependent kinase inhibitor 1B) CDKN1B Rabbit Monoclonal Antibody, Clone#RM302

Boster Bio Anti-p27Kip1 (Cyclin-dependent kinase inhibitor 1B) CDKN1B Rabbit Monoclonal Antibody, Clone#RM302 (Catalog # M00173-2) . Tested in IHC, WB applications. This antibody reacts with Human.

Product Specifications

Synonyms

Cyclin-dependent kinase inhibitor 1B; Cyclin-dependent kinase inhibitor p27 ; p27Kip1 ; CDKN1B; KIP1

Gene Name

CDKN1B

UniProt

P46527

Host

Rabbit

Reactivity

Human

Cross Reactivity

This antibody reacts to human p27Kip1 (Cyclin-dependent kinase inhibitor 1B) . It may also react to mouse p27Kip1, as predicted by immunogen homology.

Immunogen

A peptide corresponding to the C-terminus of human p27Kip1.

Clonality

Monoclonal

Clone

Clone: RM302

Tissue Specificity

Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney.

Applications

IHC, WB

Field of Research

Cancer, Cell Biology, Cell Cycle, Cell Cycle Inhibitors, Epigenetics and Nuclear Signaling

Purification

Protein A affinity purified from an animal origin-free culture supernatant

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (PubMed:28666995) . Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A- CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.

Molecular Weight

22073 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. Avoid repeated freeze-thaw cycles.

Fragment

Rabbit IgG

Other Gene Names

Cyclin-dependent kinase inhibitor 1B

Subcellular Location

Nucleus. Cytoplasm. Endosome. Nuclear and cytoplasmic in quiescent cells. AKT- or RSK- mediated phosphorylation on Thr-198, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle progression. Mitogen- activated UHMK1 phosphorylation on Ser-10 also results in translocation to the cytoplasm and cell cycle progression. Phosphorylation on Ser-10 facilitates nuclear export. Translocates to the nucleus on phosphorylation of Tyr-88 and Tyr-89. Colocalizes at the endosome with SNX6; this leads to lysosomal degradation (By similarity) .

Prediction Reactivity

Mouse

Frequently Asked Questions

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