Anti-CD11b (integrin alpha-M) ITGAM Rabbit Monoclonal Antibody, Clone#RM290

Boster Bio Anti-CD11b (integrin alpha-M) ITGAM Rabbit Monoclonal Antibody, Clone#RM290 (Catalog # M00144-2) . Tested in IHC, WB applications. This antibody reacts with Human.

Product Specifications

Synonyms

Integrin alpha-M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; CD11b; ITGAM; CD11B, CR3A

Gene Name

ITGAM

UniProt

P11215

Host

Rabbit

Reactivity

Human

Cross Reactivity

This antibody reacts to human CD11b (Integrin alpha-M)

Immunogen

A peptide corresponding to the C-terminus of human CD11b (Integrin alpha-M)

Clonality

Monoclonal

Clone

Clone: RM290

Tissue Specificity

Predominantly expressed in monocytes and granulocytes (PubMed:1346576) . Expressed in neutrophils (at protein level) (PubMed:21193407) .

Applications

IHC, WB

Field of Research

Cell Adhesion, Cell Type Marker, Cell Type Markers, Cytoskeleton/ECM, Hematopoietic Progenitors, Integrins, Lymphoid, Mesenchymal Stem Cells, Myeloid, Neuroscience, Signal Transduction, Stem Cells, T Lymphocytic Lineage

Purification

Protein A affinity purified from an animal origin-free culture supernatant

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed:28807980) . In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407) . May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity) . May play a role in mast cell development (By similarity) .