Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

DA-6886 (monohydrochloride)

DA-6886 is a 5-Hydroxytryptamine receptor 4 (5-HT4) agonist. DA-6886 induces relaxation of the rat oesophagus preparation in a 5-HT4 receptor antagonist-sensitive manner. The evaluation of DA-6886 in CHO cells expressing hERG channels reveals that it inhibits hERG channel current with an pIC50 value of 4.3, indicating that the compound is 1000-fold more selective for the 5-HT4 receptor over hERG channels. DA-6886 can be used in the study of constipated irritable bowel syndrome[1][2].

Product Specifications

CAS Number

1645260-76-9

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/da-6886-monohydrochloride.html

Smiles

O=C(NCC1CCN(CCCN2N=NC=C2)CC1)C3=CC(Cl)=C(N)C=C3OC.Cl

Molecular Formula

C19H28Cl2N6O2

Molecular Weight

443.37

References & Citations

[1]Lee D Y, et al. Pharmacokinetics of DA-6886, a new 5-HT4 receptor agonist, in rats[J]. Pharmaceutics, 2022, 14 (4) : 702.|[2]Lee M J, et al. Pharmacological profile of DA-6886, a novel 5-HT4 receptor agonist to accelerate colonic motor activity in mice[J]. European Journal of Pharmacology, 2014, 735: 115-122.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 1

Isoform

Apolipoprotein D

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

GST Goat Polyclonal Antibody
AB9929-200 600 µg

GST Goat Polyclonal Antibody

Sign In for Pricing
View Details
Human LOC284898 activation kit by CRISPRa
GA117182 1 Kit

Human LOC284898 activation kit by CRISPRa

Sign In for Pricing
View Details
Frozen Tissue Blocks, Kidney
CB610708 1 Block

Frozen Tissue Blocks, Kidney

Sign In for Pricing
View Details
Elab Fluor® Violet 540 Anti-Mouse Ly6G Antibody[1A8]
E-AB-F1108UT3-01 25 µg

Elab Fluor® Violet 540 Anti-Mouse Ly6G Antibody[1A8]

Sign In for Pricing
View Details
Elab Fluor® Violet 540 Anti-Mouse Ly6G Antibody[1A8]
E-AB-F1108UT3-02 100 µg

Elab Fluor® Violet 540 Anti-Mouse Ly6G Antibody[1A8]

Sign In for Pricing
View Details
NUP43 Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI6E11]
TA807567AM 100 µL

NUP43 Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI6E11]

Sign In for Pricing
View Details