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DA-6886 (monohydrochloride)

DA-6886 is a 5-Hydroxytryptamine receptor 4 (5-HT4) agonist. DA-6886 induces relaxation of the rat oesophagus preparation in a 5-HT4 receptor antagonist-sensitive manner. The evaluation of DA-6886 in CHO cells expressing hERG channels reveals that it inhibits hERG channel current with an pIC50 value of 4.3, indicating that the compound is 1000-fold more selective for the 5-HT4 receptor over hERG channels. DA-6886 can be used in the study of constipated irritable bowel syndrome[1][2].

Product Specifications

CAS Number

1645260-76-9

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/da-6886-monohydrochloride.html

Smiles

O=C(NCC1CCN(CCCN2N=NC=C2)CC1)C3=CC(Cl)=C(N)C=C3OC.Cl

Molecular Formula

C19H28Cl2N6O2

Molecular Weight

443.37

References & Citations

[1]Lee D Y, et al. Pharmacokinetics of DA-6886, a new 5-HT4 receptor agonist, in rats[J]. Pharmaceutics, 2022, 14 (4) : 702.|[2]Lee M J, et al. Pharmacological profile of DA-6886, a novel 5-HT4 receptor agonist to accelerate colonic motor activity in mice[J]. European Journal of Pharmacology, 2014, 735: 115-122.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 1

Isoform

Apolipoprotein D

Available Sizes

Frequently Asked Questions

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