Anti-PD-L1 (CD274) (B7-H1) Rabbit Monoclonal Antibody, Clone#RM320

Boster Bio Anti-PD-L1 (CD274) (B7-H1) Rabbit Monoclonal Antibody, Clone#RM320 (Catalog # M00109-1) . Tested in IHC, WB, ICC applications. This antibody reacts with Human.

Product Specifications

Synonyms

Programmed cell death 1 ligand 1; PD-L1; PDCD1 ligand 1; Programmed death ligand 1; B7 homolog 1; B7-H1; CD274; Cd274; B7h1, Pdcd1l1, Pdcd1lg1, Pdl1

Gene Name

Cd274

UniProt

Q9EP73

Host

Rabbit

Reactivity

Human

Cross Reactivity

This antibody reacts to human PD-L1 (CD274) (B7-H1)

Immunogen

A peptide corresponding to the C-terminus of human PD-L1

Clonality

Monoclonal

Clone

Clone: RM320

Tissue Specificity

Highly expressed in the heart, thymus, skeletal muscle, and lung. Weakly expressed in the kidney, spleen, thyroid, and liver. Expressed on activated dendritic cells, B- cells and macrophages. Expressed in numerous tumor cells lines of lymphoid origin.

Applications

IHC, WB, ICC

Field of Research

Autoimmune, Cancer, Cell Type Markers, Immune System Diseases, Immunology, Tumor Antigens, Tumor Biomarkers, Tumor Immunology, Tumor-Associated Antigens

Purification

Protein A affinity purified from an animal origin-free culture supernatant

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1, modulates the activation threshold of T-cells and limits T- cell effector response (PubMed:11238124) . The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (By similarity) . May costimulate helper T-cell subsets through a yet unknown activating receptor (PubMed:11015443, PubMed:12719480) .

Molecular Weight

32780 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. Avoid repeated freeze-thaw cycles.

Fragment

Rabbit IgG

Other Gene Names

Programmed cell death 1 ligand 1

Subcellular Location

Cell membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein. Recycling endosome membrane; Single-pass type I membrane protein.