Anti-E-Cadherin 1 (CDH1) Rabbit Monoclonal Antibody, Clone#RM244

Boster Bio Anti-E-Cadherin 1 (CDH1) Rabbit Monoclonal Antibody, Clone#RM244 (Catalog # M00063-3) . Tested in IHC, WB applications. This antibody reacts with Human.

Product Specifications

Synonyms

Cadherin-1; CAM 120/80; Epithelial cadherin; E-cadherin; Uvomorulin; CD324; E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3; CDH1; CDHE, UVO

Gene Name

CDH1

UniProt

P12830

Host

Rabbit

Reactivity

Human

Cross Reactivity

This antibody reacts to human E-cadherin (Cadherin-1) .

Immunogen

A peptide corresponding to Cadherin-1

Clonality

Monoclonal

Clone

Clone: RM244

Tissue Specificity

Non-neural epithelial tissues.

Applications

IHC, WB

Field of Research

Cadherins, Calcium Binding Proteins, Calcium Signaling, Cancer, Cell Adhesion, Cytoskeleton/ECM, Invasion/Microenvironment, Signal Transduction, Signaling Pathway

Purification

Protein A affinity purified from an animal origin-free culture supernatant

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333) . They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333) . Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.

Molecular Weight

97456 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. Avoid repeated freeze-thaw cycles.

Fragment

Rabbit IgG

Other Gene Names

Cadherin-1

Subcellular Location

Cell junction. Cell membrane; Single-pass type I membrane protein. Endosome. Golgi apparatus, trans-Golgi network. Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Colocalizes with RAB11A endosomes during its transport from the Golgi apparatus to the plasma membrane.