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Anti-MeCP2 Antibody

Boster Bio Anti-MeCP2 Antibody catalog # M00047-1. Tested in IF, IHC, ICC, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat.

Product Specifications

Synonyms

Methyl-CpG-binding protein 2; MeCp-2 protein; MeCp2; MECP2

Gene Name

MECP2

UniProt

P51608

Host

Rabbit

Reactivity

Human, Monkey, Rat, Mouse

Immunogen

Full length recombinant human MeCP2

Clonality

Polyclonal

Tissue Specificity

Present in all adult somatic tissues tested.

Applications

IHC, WB, IF, ICC

Field of Research

2339, Epigenetics and Nuclear Signaling, Neurodegenerative Disease, Neurology Process, Neuroscience

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Dilution

WB: 1:10,000-1:20,000 IF/ICC or IHC: 1:2,000

Function

Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) -containing DNA, with a preference for 5-methylcytosine (5mC) . .

Molecular Weight

52441 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Other Gene Names

Methyl-CpG-binding protein 2

Subcellular Location

Nucleus . Colocalized with methyl-CpG in the genome. Colocalized with TBL1X to the heterochromatin foci. .

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