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Anti-MYD88 Rabbit Monoclonal Antibody, Clone#RM306

Boster Bio Anti-MYD88 Rabbit Monoclonal Antibody, Clone#RM306 (Catalog # M00025-1) . Tested in IHC, WB applications. This antibody reacts with Human.

Product Specifications

Synonyms

Myeloid differentiation primary response protein MyD88; MYD88

Gene Name

MYD88

UniProt

Q99836

Host

Rabbit

Reactivity

Human

Cross Reactivity

This antibody reacts to human myeloid differentiation primary response protein MyD88

Immunogen

A peptide corresponding to the N-terminus of human MyD88

Clonality

Monoclonal

Clone

Clone: RM306

Tissue Specificity

Ubiquitous.

Applications

IHC, WB

Field of Research

Adapters, Atherosclerosis, Cardiovascular, Cytoplasmic, Immunology, Innate Immunity, Signal Transduction, TLR Signaling, Vascular Inflammation

Purification

Protein A affinity purified from an animal origin-free culture supernatant

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine.

Molecular Weight

33233 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. Avoid repeated freeze-thaw cycles.

Fragment

Rabbit IgG

Other Gene Names

Myeloid differentiation primary response protein MyD88

Subcellular Location

Cytoplasm.

Frequently Asked Questions

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