Anti-MYD88 Rabbit Monoclonal Antibody, Clone#RM306

Boster Bio Anti-MYD88 Rabbit Monoclonal Antibody, Clone#RM306 (Catalog # M00025-1) . Tested in IHC, WB applications. This antibody reacts with Human.

Product Specifications

Synonyms

Myeloid differentiation primary response protein MyD88; MYD88

Gene Name

MYD88

UniProt

Q99836

Host

Rabbit

Reactivity

Human

Cross Reactivity

This antibody reacts to human myeloid differentiation primary response protein MyD88

Immunogen

A peptide corresponding to the N-terminus of human MyD88

Clonality

Monoclonal

Clone

Clone: RM306

Tissue Specificity

Ubiquitous.

Applications

IHC, WB

Field of Research

Adapters, Atherosclerosis, Cardiovascular, Cytoplasmic, Immunology, Innate Immunity, Signal Transduction, TLR Signaling, Vascular Inflammation

Purification

Protein A affinity purified from an animal origin-free culture supernatant

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine.