Anti-p16INK4a (CDKN2A) Rabbit Monoclonal Antibody, Clone#RM267

Boster Bio Anti-p16INK4a (CDKN2A) Rabbit Monoclonal Antibody, Clone#RM267 (Catalog # M00016-1) . Tested in IHC, WB applications. This antibody reacts with Human.

Product Specifications

Synonyms

Cyclin-dependent kinase inhibitor 2A ; Cyclin-dependent kinase 4 inhibitor A; CDK4I; Multiple tumor suppressor 1; MTS-1; p16-INK4a; p16-INK4; p16INK4A; CDKN2A ; CDKN2, MTS1

Gene Name

CDKN2A

UniProt

P42771

Host

Rabbit

Reactivity

Human

Cross Reactivity

This antibody reacts to human p16INK4a (Cyclin-dependent kinase inhibitor 2A) .

Immunogen

A peptide corresponding to the C-terminus of human p16INK4a (Cyclin-dependent kinase inhibitor 2A) .

Clonality

Monoclonal

Clone

Clone: RM267

Tissue Specificity

Widely expressed but not detected in brain or skeletal muscle. Isoform 3 is pancreas-specific.

Applications

IHC, WB

Field of Research

Cancer, Cancer Susceptibility, Cell Biology, Cell Cycle, Cell Cycle Inhibitors, Epigenetics and Nuclear Signaling, Oncoproteins/Suppressors, p53 Pathway, Transcription, Tumor Suppressors

Purification

Protein A affinity purified from an animal origin-free culture supernatant

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.