DNA Ligase IV Antibody (Clone 4D9)

<strong>DNA Ligase IV Antibody (Clone 4D9)</strong>_x000D_ <strong>Catalog number:</strong> B2015158_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 100 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 6 kDa_x000D_ <strong>Supplied as:</strong> N/A_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> 2 - 8 °C_x000D_ <strong>Keywords:</strong> DNA Ligase IV Antibody (D-8)_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Gibson DG. Enzymatic assembly of overlapping DNA fragments Methods Enzymol. 2011;498:349-61._x000D_ 2: Robins P, Lindahl T. DNA ligase IV from HeLa cell nuclei J Biol Chem. 1996 Sep 27;271(39):24257-61._x000D_ 3: Zhang B, Liu Q, Wen W, Gao H, Wei W, Tang A, Qin B, Lyu H, Meng X, Li K, Jin H, Yu F, Pan Q, Lin J, Lee MH. The chromatin remodeler CHD6 promotes colorectal cancer development by regulating TMEM65-mediated mitochondrial dynamics via EGF and Wnt signaling Cell Discov. 2022 Dec 6;8(1):130._x000D_ 4: Gerodimos CA, Chang HHY, Watanabe G, Lieber MR. Effects of DNA end configuration on XRCC4-DNA ligase IV and its stimulation of Artemis activity J Biol Chem. 2017 Aug 25;292(34):13914-13924._x000D_ 5: Frank KM, Sekiguchi JM, Seidl KJ, Swat W, Rathbun GA, Cheng HL, Davidson L, Kangaloo L, Alt FW. Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV Nature. 1998 Nov 12;396(6707):173-7._x000D_ 6: Liang L, Deng L, Nguyen SC, Zhao X, Maulion CD, Shao C, Tischfield JA. Human DNA ligases I and III, but not ligase IV, are required for microhomology-mediated end joining of DNA double-strand breaks Nucleic Acids Res. 2008 Jun;36(10):3297-310._x000D_ 7: Nishida Y, Mizutani N, Inoue M, Omori Y, Tamiya-Koizumi K, Takagi A, Kojima T, Suzuki M, Nozawa Y, Minami Y, Ohnishi K, Naoe T, Murate T. Phosphorylated Sp1 is the regulator of DNA-PKcs and DNA ligase IV transcription of daunorubicin-resistant leukemia cell lines Biochim Biophys Acta. 2014;1839(4):265-74._x000D_ 8: Park J, Welner RS, Chan MY, Troppito L, Staber PB, Tenen DG, Yan CT. The DNA Ligase IV Syndrome R278H Mutation Impairs B Lymphopoiesis via Error-Prone Nonhomologous End-Joining J Immunol. 2016 Jan 1;196(1):244-55._x000D_ 9: Vago R, Leva V, Biamonti G, Montecucco A. DNA ligase I and Nbs1 proteins associate in a complex and colocalize at replication factories Cell Cycle. 2009 Aug 15;8(16):2600-7._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/1695631">10: Tomkinson AE, Lasko DD, Daly G, Lindahl T. Mammalian DNA ligases. Catalytic domain and size of DNA ligase I J Biol Chem. 1990 Jul 25;265(21):12611-7.</a>_x000D_ _x000D_ <strong>Products Related to DNA Ligase IV Antibody (Clone 4D9) can be found at</strong> <a href="https://moleculardepot.com/product-category/Antibodies/"> Antibodies</a>