Anti-human CD71 TFRC Monoclonal Antibody Biotin Conjugated, Flow Validated

Boster Bio Anti-human CD71 TFRC Monoclonal Antibody Biotin Conjugated, Flow Validated (Catalog# FC00591-Biotin) . Tested in Flow Cytometry application (s) . This antibody reacts with Human.

Product Specifications

Background

CD71 is also known as transferrin receptor (TFRC) . Nikinmaa and Schroder (1987) concluded that p90 and TFRC are the same protein: studies using monoclonal antibodies indicated that exhaustive precipitation of radioactively labeled lysates with one antibody removed all activity of lysates with the other. Peptide maps of antigens recognized with both antibodies showed great similarity and indicated that both antibodies react with the same antigen, the human transferrin receptor, but with different antigenic sites of the molecule.TFR is assigned to chromosome 3.

Synonyms

Transferrin receptor protein 1; TR; TfR; TfR1; Trfr; T9; p90; CD71; Transferrin receptor protein 1, serum form; sTfR; TFRC

Gene Name

TFRC

UniProt

P02786

Host

Mouse

Reactivity

Human

Immunogen

Human acute lymphoblastic leukaemia cells

Clonality

Monoclonal

Clone

Clone: Clone: OKT9

Conjugation

Biotin

Applications

Flow Cytometry

Field of Research

Cancer, Cancer Metabolism, Cardiovascular, Cell Type Markers, Hematopoietic Progenitors, Immunology, Lymphoid, Metabolism, Metabolism Processes, Myeloid, Neural Stem Cells, Pathways and Processes, Response To Hypoxia, Serum Proteins, Stem Cells, Surface Molecules, T Lymphocytic Lineage

Purification

Protein A purified

Sensitivity

5ul per sample

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Dilution

User needs to optimize the dilution ratio for this antibody.

Form

Liquid

Function

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity) . A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. .