Anti-BCMA TNFRSF17 Antibody (Monoclonal, Vicky-1), PE Conjugated

Boster Bio Anti-BCMA TNFRSF17 Antibody (Monoclonal, Vicky-1), PE Conjugated catalog # E01014. Tested in Flow Cytometry applications. This antibody reacts with Human.

Product Specifications

Background

TNFRSF17 (Tumor necrosis factor receptor superfamily member 17), also called BCMA, is a protein that in humans is encoded by the TNFRSF17 gene. The protein encoded by this gene is a member of the TNF-receptor superfamily and is mapped to 16p13.13. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.

Synonyms

Tumor necrosis factor receptor superfamily member 17; B-cell maturation protein; CD269; TNFRSF17; BCM, BCMA

Gene Name

TNFRSF17

UniProt

Q02223

Host

Rat

Reactivity

Human

Cross Reactivity

No cross reactivity with other proteins.

Immunogen

Recombinant human BCMA extracellular domain (aa 2-54) .

Clonality

Monoclonal

Clone

Clone: Vicky-1

Conjugation

Tissue Specificity

Expressed in mature B-cells, but not in T- cells or monocytes.

Applications

Flow Cytometry

Field of Research

Antiviral Signaling, Cancer, Growth Factors, Growth Factors/Hormones, Immune System Diseases, Immunology, Signal Transduction

Purification

Protein G-affinity purified.

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Dilution

Flow Cytometry, 1:100, Human

Form

Liquid

Function

Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. .