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Anti-MRGX1 MRGPRX1 Antibody

Boster Bio Anti-MRGX1 MRGPRX1 Antibody (Catalog# A30840) . Tested in WB, IF, ICC, ELISA applications. This antibody reacts with Human, Rat, Mouse.

Product Specifications

Synonyms

MRGPRX1; MRGX1; SNSR3; SNSR4; Mas-related G-protein coupled receptor member X1; Sensory neuron-specific G-protein coupled receptor 3/4

Gene Name

MRGPRX1

UniProt

Q96LB2

Host

Rabbit

Reactivity

Human, Rat, Mouse

Immunogen

A peptide derived from human MRGX1. Immunogen sequence location: 271 - 320

Clonality

Polyclonal

Tissue Specificity

Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.

Applications

WB, IF, ICC, ELISA

Field of Research

G Protein Signaling, Signal Transduction, Signaling Pathway

Purification

The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22) (PubMed:26582731) . BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G (alpha) q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine- induced itch, in a histamine-independent manner.

Molecular Weight

36250 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short-term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Fragment

Rabbit IgG

Other Gene Names

Mas-related G-protein coupled receptor member X1

Subcellular Location

Cell membrane; Multi-pass membrane protein.

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