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Anti-GPRC6A Antibody

Boster Bio Anti-GPRC6A Antibody (Catalog# A30829) . Tested in WB, IF, ICC, ELISA applications. This antibody reacts with Human, Rat, Mouse.

Product Specifications

Synonyms

GPRC6A; G-protein coupled receptor family C group 6 member A; hGPRC6A; G-protein coupled receptor GPCR33; hGPCR33

Gene Name

GPRC6A

UniProt

Q5T6X5

Host

Rabbit

Reactivity

Human, Rat, Mouse

Immunogen

A peptide derived from human GPRC6A. Immunogen sequence location: 471 - 520

Clonality

Polyclonal

Tissue Specificity

Isoform 1 is expressed at high level in brain, skeletal muscle, testis, bone, calvaria, osteoblasts and leukocytes. Expressed at intermediate level in liver, heart, kidney and spleen. Expressed at low level in lung, pancreas, placenta and ovary. Not detected in thymus, prostate, small intestine, tongue and colon.Isoform 1 and isoform 2 are expressed in kidney at the same level.Isoform 2 is expressed at lower level than isoform 1 in the other tissues.

Applications

WB, IF, ICC, ELISA

Field of Research

G Protein Signaling, Neuroscience, Neurotransmission, Receptors / Channels, Signal Transduction, Signaling Pathway

Purification

The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca (2+) and Mg (2+) . Activated by extracellular calcium and osteocalin. Seems to act through a G (q) /G (11) and G (i) -coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinates nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalents ions and its responsiveness to anabolic steroids.

Molecular Weight

104753 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short-term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Fragment

Rabbit IgG

Other Gene Names

G-protein coupled receptor family C group 6 member A

Subcellular Location

Cell membrane; Multi-pass membrane protein.

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