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Anti-GPR143/Oa1 Antibody

Boster Bio Anti-GPR143/Oa1 Antibody (Catalog# A30809) . Tested in IF, ICC, ELISA applications. This antibody reacts with Human, Mouse.

Product Specifications

Synonyms

GPR143; OA1; G-protein coupled receptor 143; Ocular albinism type 1 protein

Gene Name

GPR143

UniProt

P51810

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

The antiserum was produced against synthesized peptide derived from human GPR143.

Clonality

Polyclonal

Tissue Specificity

Expressed at high levels in the retina, including the retinal pigment epithelium (RPE), and in melanocytes. Weak expression is observed in brain and adrenal gland.

Applications

IF, ICC, ELISA

Field of Research

More Gpcr, Neuroscience, Neurotransmission, Receptors / Channels, Sensory System, Visual System

Purification

The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca (2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand- dependent signaling occurs through a G (q) -mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport.

Molecular Weight

43878 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short-term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Fragment

Rabbit IgG

Other Gene Names

G-protein coupled receptor 143

Subcellular Location

Melanosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Distributed throughout the endo-melanosomal system but most of endogenous protein is localized in unpigmented stage II melanosomes. Its expression on the apical cell membrane is sensitive to tyrosine (PubMed:18828673) .

Frequently Asked Questions

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