What is the catalog number for Anti-NEURL1 Antibody?

The catalog number for Anti-NEURL1 Antibody is A30740.

What sizes are available for Anti-NEURL1 Antibody?

Anti-NEURL1 Antibody is available in the following size(s): 100 µL.

Is Anti-NEURL1 Antibody in stock?

Anti-NEURL1 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Where can I find the safety data sheet (SDS/MSDS) for Anti-NEURL1 Antibody?

The safety data sheet for Anti-NEURL1 Antibody is available here: https://www.bosterbio.com/msds?sku=A30740.

Anti-NEURL1 Antibody

Boster Bio Anti-NEURL1 Antibody (Catalog# A30740) . Tested in WB, IHC-P, IF (paraffin), ELISA applications. This antibody reacts with Human, Rat, Mouse.

Product Specifications

Synonyms

NEURL; NEURL1; NEURL1A; RNF67; Neuralized-like protein 1A; h-neu; h-neuralized 1; RING finger protein 67

Gene Name

NEURL1

UniProt

O76050

Host

Rabbit

Reactivity

Human, Rat, Mouse

Immunogen

A peptide derived from human NEURL1. Immunogen sequence location: 219-268

Clonality

Polyclonal

Tissue Specificity

Expressed in brain, testis, pituitary gland, pancreas and bone marrow. Also poorly expressed in an malignant astrocytomas and several neuroectodermal tumor cell lines. Weakly expressed in medulloblastoma (MB) compared with normal cerebellar tissues.

Applications

WB, IHC-P, IF (paraffin), ELISA

Field of Research

Epigenetics and Nuclear Signaling, Ubiquitin & Ubiquitin Like Modifiers

Purification

The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.

Sensitivity

>5000 cells

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element- binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway.

Molecular Weight

61860 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short-term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Fragment

Rabbit IgG

Other Gene Names

E3 ubiquitin-protein ligase NEURL1

Subcellular Location

Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein. Perikaryon. Cell projection, dendrite. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Localized in the cell bodies of the pyramidal neurons and distributed along their apical dendrites. Colocalized with PSD95 in postsynaptic sites. Colocalized with CPEB3 at apical dendrites of CA1 neurons (By similarity) . Colocalized with JAG1 at the cell surface.