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Anti-RPC8 Antibody

Boster Bio Anti-RPC8 Antibody (Catalog# A30654) . Tested in WB, IHC-P, IF (paraffin), ELISA applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

POLR3H; KIAA1665; RPC8; DNA-directed RNA polymerase III subunit RPC8; RNA polymerase III subunit C8; DNA-directed RNA polymerase III subunit H; RNA polymerase III subunit 22.9 kDa subunit; RPC22.9

Gene Name

POLR3H

UniProt

Q9Y535

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A peptide derived from human RPC8. Immunogen sequence location: 151-200

Clonality

Polyclonal

Applications

WB, IHC-P, IF (paraffin), ELISA

Field of Research

Epigenetics and Nuclear Signaling, Polymerase Associated Factors, RNA Polymerase, Transcription

Purification

The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.

Sensitivity

>5000 cells

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity) .

Molecular Weight

22918 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short-term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A30654

Product MSDS

https://www.bosterbio.com/msds?sku=A30654

Fragment

Rabbit IgG

Other Gene Names

DNA-directed RNA polymerase III subunit RPC8

Subcellular Location

Nucleus.

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