Anti-RPC4 POLR3D Antibody

Boster Bio Anti-RPC4 POLR3D Antibody (Catalog# A30652) . Tested in WB, ELISA applications. This antibody reacts with Human, Mouse.

Product Specifications

Synonyms

POLR3D; BN51; BN51T; DNA-directed RNA polymerase III subunit RPC4; RNA polymerase III subunit C4; DNA-directed RNA polymerase III subunit D; Protein BN51; RNA polymerase III 47 kDa subunit; RPC53 homolog

Gene Name

POLR3D

UniProt

P05423

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

A peptide derived from human RPC4. Immunogen sequence location: 281-330

Clonality

Polyclonal

Applications

WB, ELISA

Field of Research

Epigenetics and Nuclear Signaling, Polymerase Associated Factors, RNA Polymerase, Transcription

Purification

The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity) .