Anti-CLIP-associating protein 1 CLASP1 Antibody

Boster Bio Anti-CLIP-associating protein 1 CLASP1 Antibody (Catalog# A30619) . Tested in WB, IHC-P, IF (paraffin), ELISA applications. This antibody reacts with Human, Mouse.

Product Specifications

Synonyms

CLASP1; KIAA0622; MAST1; CLIP-associating protein 1; Cytoplasmic linker-associated protein 1; Multiple asters homolog 1; Protein Orbit homolog 1; hOrbit1

Gene Name

CLASP1

UniProt

Q7Z460

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

A peptide derived from human CLASP1. Immunogen sequence location: 1171-1220

Clonality

Polyclonal

Applications

WB, IHC-P, IF (paraffin), ELISA

Field of Research

Cell Biology, Cell Cycle, Cell Division, Spindle

Purification

The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN) . Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.

Molecular Weight

169451 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short-term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A30619

Product MSDS

https://www.bosterbio.com/msds?sku=A30619

Fragment

Rabbit IgG

Other Gene Names

CLIP-associating protein 1

Subcellular Location

Cytoplasm, cytoskeleton.Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore.Cytoplasm, cytoskeleton, spindle. Golgi apparatus, trans-Golgi network. Localizes to microtubule plus ends. Localizes to centrosomes, kinetochores and the mitotic spindle from prometaphase. Subsequently localizes to the spindle midzone from anaphase and to the midbody from telophase. In migrating cells localizes to the plus ends of microtubules within the cell body and to the entire microtubule lattice within the lamella. Localizes to the cell cortex and this requires ERC1 and PHLDB2.