Anti-HUCE1 Antibody

Boster Bio Anti-HUCE1 Antibody (Catalog# A30608) . Tested in WB, IHC-P, IF (paraffin), ELISA applications. This antibody reacts with Human, Rat, Mouse.

Product Specifications

Synonyms

RRP8; KIAA0409; NML; hucep-1; Ribosomal RNA-processing protein 8; Cerebral protein 1; Nucleomethylin

Gene Name

RRP8

UniProt

O43159

Host

Rabbit

Reactivity

Human, Rat, Mouse

Immunogen

A peptide derived from human HUCE1. Immunogen sequence location: 271-320

Clonality

Polyclonal

Applications

WB, IHC-P, IF (paraffin), ELISA

Purification

The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD (+) /NADP (+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys- 9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.