Anti-JIP2 MAPK8IP2 Antibody

Boster Bio Anti-JIP2 MAPK8IP2 Antibody (Catalog# A30484) . Tested in WB, IHC-P, IF, ICC, ELISA applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

MAPK8IP2; IB2; JIP2; PRKM8IPL; C-Jun-amino-terminal kinase-interacting protein 2; JIP-2; JNK-interacting protein 2; Islet-brain-2; IB-2; JNK MAP kinase scaffold protein 2; Mitogen-activated protein kinase 8-interacting protein 2

Gene Name

MAPK8IP2

UniProt

Q13387

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A peptide derived from human JIP2. Immunogen sequence location: 581-630

Clonality

Polyclonal

Tissue Specificity

Expressed mainly in the brain and pancreas, including insulin-secreting cells. In the nervous system, more abundantly expressed in the cerebellum, pituitary gland, occipital lobe and the amygdala. Also expressed in fetal brain. Very low levels found in uterus, ovary, prostate, colon, testis, adrenal gland, thyroid gland and salivary gland.

Applications

WB, IHC-P, IF, ICC, ELISA

Field of Research

Adapters, Cytoplasmic, MAPK Pathway, Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction

Purification

The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity) .