α2A-AR agonist 1
α2A-AR agonist 1 (Compound B9) is a selective agonist for α2-adrenergic receptor (α2A-AR) with EC50 of 0.23 nM. α2A-AR agonist 1 exhibits a hypnotic effect, with ED50 of 0.138 mg/kg in the loss of righting reflex (LORR) experiment. α2A-AR agonist 1 exhibits metabolic stability in mouse liver microsomes[1].
Product Specifications
CAS Number
[2971825-58-6]
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/α2a-ar-agonist-1.html
Purity
99.92
Solubility
DMSO : 87.5 mg/mL (ultrasonic)
Smiles
BrC1=C(C2=CC=C1)OCCC2C3=CNC=N3
Molecular Formula
C12H11BrN2O
Molecular Weight
279.13
References & Citations
[1]Lv X, et al., Designing Chromane Derivatives as α2A-Adrenoceptor Selective Agonists via Conformation Constraint. J Med Chem. 2024 Jun 18.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
α adrenergic receptor
Available Sizes
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