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Anti-CBCP6 Antibody

Boster Bio Anti-CBCP6 Antibody (Catalog # A14810) . Tested in WB applications. This antibody reacts with Human.

Product Specifications

Background

Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5 By similarity.<br><br>Ota T., Nat. Genet. 36:40-45(2004).<br>Gregory S.G., Nature 441:315-321(2006).

Synonyms

Cytosolic carboxypeptidase 6;3.4.17.-; ATP/GTP-binding protein-like 4; AGBL4; CCP6

Gene Name

AGBL4

UniProt

Q5VU57

Host

Rabbit

Reactivity

Human

Immunogen

Synthesized peptide derived from internal of human CBCP6.

Clonality

Polyclonal

Applications

WB

Field of Research

Cell Biology, Cytoskeleton, Cytoskeleton/ECM, Microtubules, Proteolysis/Ubiquitin, Proteolytic Enzymes, Signal Transduction, Tubulin

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Dilution

Western blotting: 1:500~1:3000

Form

Liquid

Function

Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes polyglutamates from the carboxy-terminus of target proteins such as MYLK. Mediates deglutamylation of CGAS/MB21D1, regulating the antiviral activity of CGAS/MB21D1. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. .

Molecular Weight

58230 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Other Gene Names

Cytosolic carboxypeptidase 6

Subcellular Location

Cytoplasm, cytosol . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Golgi apparatus . Cytoplasm, cytoskeleton, cilium basal body . Colocalizes with gamma-tubulin in the centrioles at interphase and dividing cells and with glutamylated tubulin in basal bodies of ciliated cells. .

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