Anti-KLHL22 Monoclonal Antibody
Boster Bio Anti-KLHL22 Monoclonal Antibody catalog # A12497. Tested in IF, IHC, WB applications. This antibody reacts with Human.
Product Specifications
Synonyms
Kelch-like protein 22; KLHL22
Gene Name
KLHL22
UniProt
Q53GT1
Host
Mouse
Reactivity
Human
Immunogen
Purified recombinant fragment of human KLHL22 expressed in E. Coli.
Clonality
Monoclonal
Clone
Clone: 7B1
Applications
WB, IHC, IF
Purification
Ascitic fluid
Form
Liquid
Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR (KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation. .
Molecular Weight
71667 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.bosterbio.com/datasheet?sku=A12497
Product MSDS
https://www.bosterbio.com/msds?sku=A12497
Other Gene Names
Kelch-like protein 22
Subcellular Location
Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle . Mainly. cytoplasmic in prophase and prometaphase. Associates with the mitotic spindle as the cells reach chromosome bi-orientation. Localizes to the centrosomes shortly before cells enter anaphase After anaphase onset, predominantly associates with the polar microtubules connecting the 2 opposing centrosomes and gradually diffuses into the cytoplasm during telophase.
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