Anti-DEDD2 (DED4) Antibody

Boster Bio Anti-DEDD2 (DED4) Antibody (Catalog# A11263) . Tested in WB application (s) . This antibody reacts with Canine, Rat, Mouse, Human.

Product Specifications

Synonyms

DNA-binding death effector domain-containing protein 2; DED-containing protein FLAME-3; FADD-like anti-apoptotic molecule 3; DEDD2; FLAME3; PSEC0004

Gene Name

DEDD2

UniProt

Q8WXF8

Host

Rabbit

Reactivity

Canine, Rat, Mouse, Human

Immunogen

A synthetic peptide of DEDD2 (DED4) protein (amino acids 210-228 GPALEQGVASRRPQALARQ)

Clonality

Polyclonal

Tissue Specificity

Expressed in most tissues. High levels were found in liver, kidney, heart, ovary, spleen, testes, skeletal muscle and peripheral blood leukocytes. Expression was absent or low in colon and small intestine. Expression is relatively high in the tumor cell lines chronic myologenous leukemia K-562 and the colorectal adenocarcinoma SW480. Expression is moderate in the cervical carcinoma HeLa, the Burkitt's lymphoma Raji, the lung carcinoma A-549, and the melanoma G-361. In contrast, two leukemia cell lines, HL-60 (promyelocytic leukemia) and MOLT-4 (lymphoblastic leukemia), show relatively low levels.

Applications

Field of Research

Apoptosis, Cell Biology, Receptors

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Dilution

WB: 1:1000-1:5000

Form

Liquid

Function

May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3.