Anti-Monoacylglycerol lipase ABHD2 ABHD2 Antibody

Monoacylglycerol lipase ABHD2 ;3.1.1.23 ;2-arachidonoylglycerol hydrolase ; Abhydrolase domain-containing protein 2 ; Lung alpha/beta hydrolase 2 ; Protein PHPS1-2 ; ABHD2 ; LABH2

Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane (PubMed:26989199) . Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA) (PubMed:26989199) . Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (PubMed:26989199) . May also play a role in smooth muscle cells migration (By similarity) . .