PF-06939999
PF-06939999 (PRMT5-IN-3) is a SAM-competitive, orally active PRMT5 inhibitor that inhibits the expression of SDMA protein (IC50 in A427 is 1.1 nM) . PF-06939999 exhibits antitumor effect[1][2].
Product Specifications
CAS Number
2159123-14-3
Product Name Alternative
PRMT5-IN-3
UNSPSC
12352005
Target
Apoptosis; Histone Methyltransferase
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pf-06939999.html
Purity
99.84
Solubility
DMSO : ≥ 100 mg/mL|H2O : 100 mg/mL (ultrasonic)
Smiles
O[C@@H]1[C@H](O)[C@@H](OC2=CC(C(F)F)=C(F)C3=C2CNCC3)C[C@H]1N4C=CC5=C(C)N=CN=C54
Molecular Formula
C22H23F3N4O3
Molecular Weight
448.44
References & Citations
[1]Adli M. Combinatorial drug treatment of cancer. WO2020198601A1.|[2]Jensen-Pergakes K, et al., SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance. Mol Cancer Ther. 2022 Jan;21 (1) :3-15.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
PRMT5
Available Sizes
Frequently Asked Questions
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