Anti-RNF144b/Ibrdc2 Antibody
Boster Bio Anti-RNF144b/Ibrdc2 Antibody catalog # A10490. Tested in WB applications. This antibody reacts with Human, Mouse.
Product Specifications
Synonyms
E3 ubiquitin-protein ligase RNF144B;6.3.2.-; IBR domain-containing protein 2; RING finger protein 144B; p53-inducible RING finger protein; RNF144B; IBRDC2, P53RFP
Gene Name
RNF144B
UniProt
Q7Z419
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from the Internal region of human p53RFP.
Tissue Specificity
Broadly expressed, with lowest levels in brain and thymus, and highest levels detectable in heart, ovary and testis. .
Applications
WB
Purification
Immunogen affinity purified
Concentration
1 mg/ml
Form
Liquid
Function
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se. .
Molecular Weight
33697 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Fragment
IgG
Other Gene Names
E3 ubiquitin-protein ligase RNF144B
Subcellular Location
Mitochondrion membrane ; Single-pass membrane protein . Cytoplasm . Mostly cytosololic, accumulates in submitochondrial domains specifically upon apoptosis induction, in synchrony with BAX activation.
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