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Anti-CHML/Rep 2 Antibody

Boster Bio Anti-CHML/Rep 2 Antibody (Catalog # A08815) . Tested in WB, IHC applications. This antibody reacts with Human.

Product Specifications

Background

Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family.<br><br>Cremers F.P.M., Hum. Mol. Genet. 1:71-75(1992).<br>Kasper G., Gene 295:27-32(2002).<br>Ota T. Nat. Genet. 36:40-45(2004)

Synonyms

Rab proteins geranylgeranyltransferase component A 2; Choroideremia-like protein; Rab escort protein 2; REP-2; CHML; REP2

Gene Name

CHML

UniProt

P26374

Host

Rabbit

Reactivity

Human

Immunogen

Synthesized peptide derived from internal of human CHML.

Clonality

Polyclonal

Applications

WB, IHC

Field of Research

Neuroscience, Neurotransmission, Protein Trafficking, Secretory Vesicles, Signal Transduction, Vesicle Transport

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family. .

Molecular Weight

74071 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Other Gene Names

Rab proteins geranylgeranyltransferase component A 2

Subcellular Location

Cytoplasm, cytosol .

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