Anti-FIR FARP2 Antibody

Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion By similarity.<br><br>Nagase T., DNA Res. 5:31-39(1998).<br>The MGC Project Team, Genome Res. 14:2121-2127(2004).<br>Jandrig B., Oncogene 23:9295-9302(2004).

FERM, RhoGEF and pleckstrin domain-containing protein 2; FERM domain including RhoGEF; FIR; Pleckstrin homology domain-containing family C member 3; PH domain-containing family C member 3; FARP2; KIAA0793, PLEKHC3

Axonal Guidance Proteins, G Protein Signaling, Growth and Development, Neural Signal Transduction, Neurology Process, Neuroscience, Ras Family, Regulators, Signal Transduction, Signaling Pathway, Small G Proteins

Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity) . .