Anti-CLECSF6 CLEC4A Antibody

C-type lectin domain family 4 member A; C-type lectin DDB27; C-type lectin superfamily member 6; Dendritic cell immunoreceptor; Lectin-like immunoreceptor; CLEC4A; CLECSF6, DCIR, LLIR; HDCGC13P

Expressed in dendritic cells, myeloid cells, B-cells and HL-60 cells (at protein level) . TNF alpha, IL-1 alpha, and LPS, down-regulated expression at the surface of neutrophils (at protein level) . Expressed preferentially in hematopoietic tissues. Expressed in peripheral blood leukocytes, neutrophils, moderate quantities in spleen, lymph node, and bone marrow, and at very low levels in thymus. Expressed in Ag-presenting cells (DC, monocytes, macrophages and B-cells), as well as on granulocytes. Expression was decreased in DC by signals inducing its maturation (e.g. CD40 ligand, LPS, and TNF alpha) . .

May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation. May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. .