Anti-ERLIN1/2 Antibody
Boster Bio Anti-ERLIN1/2 Antibody catalog # A08034-1. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Erlin-1; Endoplasmic reticulum lipid raft-associated protein 1; Protein KE04; Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1; SPFH domain-containing protein 1; ERLIN1; C10orf69, KE04, KEO4, SPFH1
Gene Name
ERLIN1
UniProt
O75477
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from ERLIN1/2 at AA range: 31-80
Tissue Specificity
Expressed in heart, placenta, liver, kidney, pancreas, prostate, testis, ovary and small intestine. .
Applications
WB, IHC
Purification
Immunogen affinity purified
Dilution
WB, 1:500-2000
Form
Liquid
Function
Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) . Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex (PubMed:24217618) . .
Molecular Weight
38926 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Erlin-1
Subcellular Location
Endoplasmic reticulum membrane ; Single-pass type II membrane protein . Associated with lipid raft-like domains of the endoplasmic reticulum membrane.
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