Anti-HORMAD1 Antibody
Boster Bio Anti-HORMAD1 Antibody catalog # A08011. Tested in WB applications. This antibody reacts with Human.
Product Specifications
Synonyms
HORMA domain-containing protein 1; Cancer/testis antigen 46; CT46; Newborn ovary HORMA protein; HORMAD1; NOHMA
Gene Name
HORMAD1
UniProt
Q86X24
Host
Rabbit
Reactivity
Human
Immunogen
The antiserum was produced against synthesized peptide derived from human HORMAD1. AA range:321-370
Tissue Specificity
Testis-specific. Over-expressed in carcinomas. .
Applications
WB
Purification
Immunogen affinity purified
Form
Liquid
Function
Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes (By similarity) . .
Molecular Weight
45200 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Fragment
IgG
Other Gene Names
HORMA domain-containing protein 1
Subcellular Location
Nucleus . Chromosome . Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the prophase I stage of meiosis. TRIP13 is required for depletion from synapsed chromosomes. The expression of the phosphorylated form at Ser-377 is restricted to unsynapsed chromosomal regions (By similarity) . .
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